Friedel-Crafts acylation reaction catalyzed by silica supported sulfonic acids: synthetic aspects and limitations

Biocatalytic Friedel–Crafts Acylation and Fries Reaction

The Friedel-Crafts acylation is commonly used for the synthesis of aryl ketones, and a biocatalytic version, which may benefit from the chemo- and regioselectivity of enzymes, has not yet been introduced. Described here is a bacterial acyltransferase which can catalyze Friedel-Crafts C-acylation of phenolic substrates in buffer without the need of CoA-activated reagents. Conversions reach up to...

Squaramide-catalyzed enantioselective Friedel-Crafts reaction of indoles with imines.

Chiral squaramides are highly enantioselective catalysts for Friedel-Crafts reaction of indoles with N-tosyl imines, affording 3-indolyl methanamine products in 85-96% yields and 84-96% ees.

Mild and Nondestructive Chemical Modification of Carbon Nanotubes (CNTs): Direct Friedel-Crafts Acylation Reaction

Friedel–Crafts acylation of 2-methoxynaphthalene over zeolite catalysts

The Friedel–Crafts acylation of 2-methoxynaphthalene was carried out in the liquid-phase batch conditions using Hmordenite, H-beta and H-Y zeolite as catalysts. All the catalysts showed 35–40% conversion in the temperature range of 100–150◦C. 1-Acyl-2-methoxynaphthalene was formed as the primary product. When acetyl chloride was used as the acylating agent, a higher yield of 6-acyl-2-methoxynap...

Asymmetric Friedel-Crafts alkylation of indole with chalcones catalyzed by chiral phosphoric acids.

The reaction of indole with chalcones, to give Michael-type adducts, was found to occur with good efficiency (up to 98% yield) and moderate enantioselectivity (up to 52% e.e.) in the presence of a chiral BINOL-based phosphoric acid. Furthermore, the alkylation products can be obtained in much higher e.e.s after one only crystallization.